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. 1989 Oct 1;170(4):1415-20.
doi: 10.1084/jem.170.4.1415.

Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production

E Sonoda  1 , R Matsumoto, Y Hitoshi, T Ishii, M Sugimoto, S Araki, A Tominaga, N Yamaguchi, K Takatsu
Affiliations

Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production

E Sonoda et al. J Exp Med. .

Abstract

Effects of transforming growth factor beta (TGF-beta) on IgA production by LPS-stimulated B cells have been studied. TGF-beta itself could augment polyclonal IgA production in concomitant inhibition of polyclonal IgM and IgG1 production. Furthermore, TGF-beta and IL-5 additively augmented IgA production. TGF-beta exerted its activity early in the culture (by 2 d in a 5-d culture) and IL-5 was required late in the culture. Surface IgA- (sIgA-) B cells responded to TGF-beta for the development of IgA-secreting cells. By contrast, sIgA+ B cells, but not sIgA- B cells, responded to IL-5 for IgA production. These results suggest that TGF-beta has a differential role in the induction of IgA production from IL-5 on murine-activated B cells.

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