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Review
. 2016 Feb:48:37-47.
doi: 10.1016/j.humpath.2015.09.035. Epub 2015 Oct 28.

The role of GATA3 in breast carcinomas: a review

Rebecca Asch-Kendrick  1 , Ashley Cimino-Mathews  2
Affiliations
Review

The role of GATA3 in breast carcinomas: a review

Rebecca Asch-Kendrick et al. Hum Pathol. 2016 Feb.

Abstract

GATA3 is a zinc-binding transcription factor that regulates the differentiation of many human tissue types, including the mammary gland. In surgical pathology, immunohistochemistry for GATA3 is largely used to support urothelial or breast origin in a carcinoma of unknown origin. GATA3 is sensitive but not entirely specific in this setting. Although GATA3 labeling is highest in estrogen receptor-positive carcinomas, it also labels estrogen receptor-negative carcinomas and thus has particular diagnostic utility in the setting of triple-negative breast carcinomas, which are typically negative for other mammary-specific markers.

Keywords: Breast cancer; Differential diagnoses; GATA3; Immunohistochemistry; Surgical pathology.

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