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Review
. 2016 Mar;10(3):475-80.
doi: 10.1016/j.molonc.2015.12.005. Epub 2015 Dec 17.

Blood circulating tumor DNA for non-invasive genotyping of colon cancer patients

Giulia Siravegna  1 , Alberto Bardelli  2
Affiliations
Review

Blood circulating tumor DNA for non-invasive genotyping of colon cancer patients

Giulia Siravegna et al. Mol Oncol. 2016 Mar.

Abstract

Most solid tumors, including colorectal cancers, shed cell-free DNA (ctDNA) in the blood. ctDNA can be analyzed to generate molecular profiles which capture the heterogeneity of the disease more comprehensively then tumor tissue biopsies. This approach commonly called 'liquid biopsy' can be applied to monitor response to therapy, to assess minimal residual disease and to uncover the emergence of drug resistance. This review will discuss current and future developments of ctDNA analysis in the clinical management of colorectal cancer patients.

Keywords: Circulating tumor DNA; Colorectal cancer; Liquid biopsy; Targeted therapy.

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References

    1. Bardelli, A. , Corso, S. , Bertotti, A. , Hobor, S. , Valtorta, E. , Siravegna, G. , Sartore-Bianchi, A. , Scala, E. , Cassingena, A. , Zecchin, D. , 2013. Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discov. 3, 658–673. - PMC - PubMed
    1. Bardelli, A. , Siena, S. , 2010. Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. J. Clin. Oncol. 28, 1254–1261. - PubMed
    1. Bertotti, A. , Migliardi, G. , Galimi, F. , Sassi, F. , Torti, D. , Isella, C. , Corà, D. , Di Nicolantonio, F. , Buscarino, M. , Petti, C. , 2011. A molecularly annotated platform of patient-derived xenografts (“xenopatients”) identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. Cancer Discov. 1, 508–523. - PubMed
    1. Bettegowda, C. , Sausen, M. , Leary, R.J. , Kinde, I. , Wang, Y. , Agrawal, N. , Bartlett, B.R. , Wang, H. , Luber, B. , Alani, R.M. , 2014. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci. Transl. Med. 6, 224ra224 - PMC - PubMed
    1. Crowley, E. , Di Nicolantonio, F. , Loupakis, F. , Bardelli, A. , 2013. Liquid biopsy: monitoring cancer-genetics in the blood. Nat. Rev. Clin. Oncol. 10, 472–484. - PubMed

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