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Meta-Analysis
. 2016 Jan 18:22:177-82.
doi: 10.12659/msm.894524.

Association of IREB2 Gene rs2568494 Polymorphism with Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis

Yiming Du  1 , Yuwen Xue  2 , Wei Xiao  2
Affiliations
Meta-Analysis

Association of IREB2 Gene rs2568494 Polymorphism with Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis

Yiming Du et al. Med Sci Monit. .

Abstract

Background: It is reported that the iron-responsive element-binding protein 2 (IREB2) gene rs2568494 polymorphism might be associated with COPD risk. The purpose of this meta-analysis was to collect all eligible studies to review the association between IREB2 gene rs2568494 polymorphism and susceptibility to COPD.

Material/methods: We carried out a comprehensive document search of electronic databases of PubMed, MEDLIN, Web of Science, and included 4 eligible studies that examined the association between IREB2 rs2568494 polymorphism and COPD susceptibility. We performed a meta-analysis of these studies based on IREB2 rs2568494 genotypes.

Results: After meta-analysis with fixed or random effects, no significant associations were found under the heterozygote model (GG/GA; OR=0.908, 95%CI: 0.790-1.043; P=0.172), homozygote model (GG/AA; OR=0.880, 95%CI: 0.497-1.557; P=0.661), dominant model (GG/AA+GA; OR=0.941, 95%CI: 0.748-1.182; P=0.599), or allelic model (G/A; OR=0.953, 95%CI: 0.770-1.179; P=0.655). However, we found a significant correlation under the recessive model (AA/GA+GG; OR=1.384, 95%CI: 1.092-1.755; P=0.007).

Conclusions: The current results revealed that there was significant association between IREB2 gene rs2568494 polymorphism with susceptibility to COPD; the presence of allelic A might a genetic factor conferring susceptibility to COPD.

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Figures

Figure 1
Figure 1
Flow diagram of study selection.
Figure 2
Figure 2
Forest plot for the association of IREB2 rs2568494 polymorphism with COPD risk; (A) Forest plot for allele model (G vs. A); (B) Forest plot for GG vs. AA; (C) Forest plot for GG vs. GA; (D) Forest plot for dominate model (GG vs. GA+AA); E forest plot for the recessive model (AA vs. GA+GG).
Figure 3
Figure 3
A funnel plot was used to assess publication bias.
See this image and copyright information in PMC

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