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Review
. 2016 Feb 17;34(8):1006-11.
doi: 10.1016/j.vaccine.2016.01.010. Epub 2016 Jan 15.

The key role of rubella virus glycoproteins in the formation of immune response, and perspectives on their use in the development of new recombinant vaccines

Ekaterina K Petrova  1 , Anastasia A Dmitrieva  2 , Ekaterina A Trifonova  2 , Nikolai A Nikitin  2 , Olga V Karpova  2
Affiliations
Review

The key role of rubella virus glycoproteins in the formation of immune response, and perspectives on their use in the development of new recombinant vaccines

Ekaterina K Petrova et al. Vaccine. .

Abstract

Rubella is a highly contagious viral disease which is mostly threatens to women of reproductive age. Existent live attenuated vaccines are effective enough, but have some drawbacks and are unusable for a certain group of people, including pregnant women and people with AIDS and other immunodeficiency. Thereby the development of alternative non-replicating, recombinant vaccines undoubtedly is needed. This review discusses the protein E1 and E2 role in formation of immune response and perspectives in development of new generation recombinant vaccines using them.

Keywords: Development of recombinant vaccines; Epitopes; Glycoproteins E1 and E2; Rubella virus.

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