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Comparative Study
. 1989 Sep 28;341(6240):299-303.
doi: 10.1038/341299a0.

Cloning and structure of a yeast gene encoding a general transcription initiation factor TFIID that binds to the TATA box

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Comparative Study

Cloning and structure of a yeast gene encoding a general transcription initiation factor TFIID that binds to the TATA box

M Horikoshi et al. Nature. .

Abstract

The TATA sequence-binding factor TFIID plays a central role both in promoter activation by RNA polymerase II and other common initiation factors, and in promoter regulation by gene-specific factors. The sequence of yeast TFIID, which seems to be encoded by a single gene, contains interesting structural motifs that are possibly involved in these functions, and is similar to sequences of bacterial sigma factors.

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