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Comment
. 2015 Dec;13(6):333-5.
doi: 10.1016/j.gpb.2015.11.002. Epub 2016 Jan 8.

A New Pathway for Senescence Regulation

Xi Cao  1 , Mo Li  2
Affiliations
Comment

A New Pathway for Senescence Regulation

Xi Cao et al. Genomics Proteomics Bioinformatics. 2015 Dec.
No abstract available

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Figures

Figure 1
Figure 1
Pathways of DDR-induced senescence Upon the signal from DDR, the two upstream kinases, ATM and ATR, are activated, initiating the senescence. Classical senescence routes consist of the p53 pathway and p16-pRB pathway, which act on arresting cell cycle. The third one is mediated by GATA4, which functions by regulating SASP, finally resulting in senescence. DDR, DNA damage response; ATM, ataxia telangiectasia mutated; ATR, ataxia telangiectasia and Rad3-related; pRB, retinoblastoma; SASP, senescence-associated secretory phenotype; PRC2, polycomb repressive complex 2; MDM2, mouse double minute 2 homolog.
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