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Comparative Study
. 2016 Apr;123(4):783-8.
doi: 10.1016/j.ophtha.2015.12.010. Epub 2016 Jan 14.

Glaucoma Structural and Functional Progression in American and Korean Cohorts

Tigran Kostanyan  1 , Kyung Rim Sung  2 , Joel S Schuman  3 , Yun Ling  4 , Katie A Lucy  1 , Richard A Bilonick  4 , Hiroshi Ishikawa  5 , Larry Kagemann  5 , Jin Y Lee  2 , Gadi Wollstein  5
Affiliations
Comparative Study

Glaucoma Structural and Functional Progression in American and Korean Cohorts

Tigran Kostanyan et al. Ophthalmology. 2016 Apr.

Abstract

Purpose: To compare the rate of glaucoma structural and functional progression in American and Korean cohorts.

Design: Retrospective longitudinal study.

Participants: Three hundred thirteen eyes from 189 glaucoma and glaucoma suspects, followed up for an average of 38 months.

Methods: All subjects were examined semiannually with visual field (VF) testing and spectral-domain optical coherence tomography. All subjects had 5 or more reliable visits.

Main outcome measurements: The rates of change of retinal nerve fiber layer (RNFL) thickness, cup-to-disc (C/D) ratios, and VF mean deviation (MD) were compared between the cohorts. Variables affecting the rate of change for each parameter were determined, including ethnicity, refraction, baseline age and disease severity, disease subtype (high- vs. normal-tension glaucoma), clinical diagnosis (glaucoma vs. glaucoma suspect), and the interactions between variables.

Results: The Korean cohort predominantly demonstrated normal-tension glaucoma, whereas the American cohort predominantly demonstrated high-tension glaucoma. Cohorts had similar VF parameters at baseline, but the Korean eyes had significantly thicker mean RNFL and larger cups. Korean glaucoma eyes showed a faster thinning of mean RNFL (mean, -0.71 μm/year vs. -0.24 μm/year; P < 0.01). There were no detectable differences in the rate of change between the glaucoma cohorts for C/D ratios and VF MD and for all parameters in glaucoma suspect eyes. Different combinations of the tested variables significantly impacted the rate of change.

Conclusions: Ethnicity, baseline disease severity, disease subtype, and clinical diagnosis should be considered when comparing glaucoma progression studies.

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Conflict of interest statement

Dr. Schuman receives royalties for intellectual property licensed by the Massachusetts Institute of Technology and Massachusetts Eye and Ear Infirmary to Zeiss.

Figures

Figure 1
Figure 1
Individual rate of change in retinal nerve fiber layer thickness accounting for baseline measurements. Red markers – American participants. Blue – Korean participants.
See this image and copyright information in PMC

Comment in

References

    1. Friedman DS, Wolfs RC, O’Colmain BJ, et al. Prevalence of open-angle glaucoma among adults in the United States. Arch Ophthalmol. 2004;122(4):532–8. - PMC - PubMed
    1. Kim JH, Kang SY, Kim NR, et al. Prevalence and characteristics of glaucoma among Korean adults. Korean J Ophthalmol. 2011;25(2):110–5. - PMC - PubMed
    1. Sommer A, Tielsch JM, Katz J, et al. Racial differences in the cause-specific prevalence of blindness in east Baltimore. N Engl J Med. 1991;325(20):1412–7. - PubMed
    1. Investigators A. The Advanced Glaucoma Intervention Study (AGIS): 9. Comparison of glaucoma outcomes in black and white patients within treatment groups. Am J Ophthalmol. 2001;132(3):311–20. - PubMed
    1. Fansi AA, Papamatheakis DG, Harasymowycz PJ. Racial variability of glaucoma risk factors between African Caribbeans and Caucasians in a Canadian urban screening population. Can J Ophthalmol. 2009;44(5):576–81. - PubMed

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