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. 2016 Apr:60:84-94.
doi: 10.1016/j.jbi.2015.12.019. Epub 2016 Jan 15.

The genomic CDS sandbox: An assessment among domain experts

Ayesha Aziz  1 , Kensaku Kawamoto  2 , Karen Eilbeck  3 , Marc S Williams  4 , Robert R Freimuth  5 , Mark A Hoffman  6 , Luke V Rasmussen  7 , Casey L Overby  8 , Brian H Shirts  9 , James M Hoffman  10 , Brandon M Welch  11
Affiliations

The genomic CDS sandbox: An assessment among domain experts

Ayesha Aziz et al. J Biomed Inform. 2016 Apr.

Abstract

Genomics is a promising tool that is becoming more widely available to improve the care and treatment of individuals. While there is much assertion, genomics will most certainly require the use of clinical decision support (CDS) to be fully realized in the routine clinical setting. The National Human Genome Research Institute (NHGRI) of the National Institutes of Health recently convened an in-person, multi-day meeting on this topic. It was widely recognized that there is a need to promote the innovation and development of resources for genomic CDS such as a CDS sandbox. The purpose of this study was to evaluate a proposed approach for such a genomic CDS sandbox among domain experts and potential users. Survey results indicate a significant interest and desire for a genomic CDS sandbox environment among domain experts. These results will be used to guide the development of a genomic CDS sandbox.

Keywords: Clinical decision support systems; Genomics; Health information technology; Medical genetics; Personalized medicine.

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Conflict of interest statement

Conflict of Interest Statement

Kensaku Kawamoto (KK) is currently or recently served as a consultant on CDS to the Office of the National Coordinator for Health IT, ARUP Laboratories, McKesson InterQual, ESAC, Inc., JBS International, Inc., Inflexxion, Inc., Intelligent Automation, Inc., Partners HealthCare, the RAND Corporation, and Mayo Clinic. KK receives royalties for a Duke University-owned CDS technology for infectious disease management known as CustomID that he helped develop. KK was formerly a consultant for Religent, Inc. and a co-owner and consultant for Clinica Software, Inc., both of which provide commercial CDS services, including through use of a CDS technology known as SEBASTIAN that KK developed. KK no longer has a financial relationship with either Religent or Clinica Software. KK has no competing interests related to OpenCDS, which is freely available to the community as an open-source resource. MH was previously employed by Cerner Corporation and is an inventor on a number of genomic CDS patents owned by Cerner Corporation but does not receive royalties or other tangible benefits from these inventions. MH owns stock in Cerner Corporation at an amount below the threshold for COI or in inaccessible funds. BHS is a consultant on the Clinical Advisory Board of Avalon Healthcare Solutions. BMW is the founder and shareholder of ItRunsInMyFamily.com, a web-based family health history tool. BMW is also the founder and shareholder of Doxy.me, a telemedicine platform. The remaining authors do not report any conflict of interest.

Figures

Figure 1
Figure 1
Technical desiderata for WGS guided CDS from Masys et al. and Welch et al.
Figure 2
Figure 2
Involvement of survey respondents with CDS and Genomics and their affiliation
Figure 3
Figure 3
Desired features of Genomic CDS Sandbox
Figure 4
Figure 4
Features relating to Availability and use of genomic CDS sandbox
Figure 5
Figure 5
Test Case studies for Sandbox
See this image and copyright information in PMC

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