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. 2015 Dec;34(12):1407-9.
doi: 10.1097/INF.0000000000000901.

Place of Interferon-γ Assay for Diagnosis of Congenital Toxoplasmosis

Emmanuelle Chapey  1 , Martine Wallon, Coralie L'Ollivier, Renaud Piarroux, François Peyron
Affiliations

Place of Interferon-γ Assay for Diagnosis of Congenital Toxoplasmosis

Emmanuelle Chapey et al. Pediatr Infect Dis J. 2015 Dec.

Abstract

The diagnosis of congenital toxoplasmosis relies mainly on serology. When results are doubtful, pediatricians have difficulties with respect to treatment. We report interferon-γ responses after the stimulation of blood by Toxoplasma gondii antigen in 17 infected infants and 80 infants free of infection. Sensitivity and specificity were 93.75% (95% confidence interval: 67%-99%) and 98.75% (95% confidence interval: 92%-99%), respectively.

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