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. 1989 Oct 11;17(19):7771-8.
doi: 10.1093/nar/17.19.7771.

A cis-acting transcription element of the c-myc gene can assume an H-DNA conformation

A J Kinniburgh  1
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Free PMC article

A cis-acting transcription element of the c-myc gene can assume an H-DNA conformation

A J Kinniburgh. Nucleic Acids Res. .
Free PMC article

Erratum in

  • Nucleic Acids Res 1989 Oct 25;17(20):8412

Abstract

I have used chemical probes and an oligonucleotide-association assay to determine the structure of a nuclease-sensitive, c-myc DNA region. I find that this DNA region can form a triplex-single stranded conformer in vitro--the H-DNA conformer. This DNA region has been shown previously to be a positive, cis-acting transcription element of the c-myc gene and to bind nuclear factors, including a base-paired ribonucleoprotein. Therefore, H-DNA may be a functionally important in vivo topoisomer where the H-DNA and B-DNA conformers have different transcriptional activities.

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References

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