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Review
. 2016 May 1:100:102-15.
doi: 10.1016/j.addr.2016.01.002. Epub 2016 Jan 11.

Amorphous powders for inhalation drug delivery

Lan Chen  1 , Tomoyuki Okuda  2 , Xiang-Yun Lu  1 , Hak-Kim Chan  3
Affiliations
Review

Amorphous powders for inhalation drug delivery

Lan Chen et al. Adv Drug Deliv Rev. .

Abstract

For inhalation drug delivery, amorphous powder formulations offer the benefits of increased bioavailability for poorly soluble drugs, improved biochemical stability for biologics, and expanded options of using various drugs and their combinations. However, amorphous formulations usually have poor physicochemical stability. This review focuses on inhalable amorphous powders, including the production methods, the active pharmaceutical ingredients and the excipients with a highlight on stabilization of the particles.

Keywords: Aerodynamic diameter; Amorphous; Dry powder inhaler; Excipient; Solubility; Spray drying; Stability.

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