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. 2016 Dec;11(6):535-542.
doi: 10.1111/ijpo.12103. Epub 2016 Jan 19.

Childhood obesity patterns and relation to middle-age sleep apnoea risk: the Bogalusa Heart Study

L A Bazzano  1 , T Hu  1 , S M Bertisch  2 , L Yao  3 , E W Harville  1 , J Gustat  1 , W Chen  1 , L S Webber  4 , T Shu  1 , S Redline  5   6
Affiliations

Childhood obesity patterns and relation to middle-age sleep apnoea risk: the Bogalusa Heart Study

L A Bazzano et al. Pediatr Obes. 2016 Dec.

Abstract

Background: Obese adults have a higher risk of obstructive sleep apnoea (OSA); however, the relationship between childhood obesity and adult OSA risk is unclear. Objectives This study aimed to examine overweight/obesity (OW) in childhood and risk of OSA in middle age.

Methods: Childhood OW status was classified as never OW, weight cycling, persistent OW and incident OW. After 35 years of follow-up, high risk for OSA was determined by a positive score in ≥2 domains on the Berlin Questionnaire with obesity removed from scoring.

Results: At initial assessment, mean (SD) age was 9.9 (2.9) years, and 23.9% were OW. Overall, 25.7% had scores indicating a high risk for OSA. Compared with participants who were never OW, those with persistent OW and incident OW were 1.36 (95%CI: 1.04-1.77) and 1.47 (1.11-1.96) times more likely to be high risk for OSA, after adjustment for multiple risk factors and adult OW status. Participants with an OW duration of 1-4 years, 5-8 years, and 8+ years were 0.96 (0.44-2.09), 1.20 (0.70-2.04) and 1.52 (1.22-1.90) times more likely to be high risk for OSA compared with those who were never OW (P for trend: 0.0002).

Conclusions: These results suggest that childhood OW is associated with a high risk of OSA in middle age.

Keywords: childhood obesity; cohort study; obesity duration; obstructive sleep apnoea.

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Conflict of interest statement

Statement The authors have no conflicts of interest relevant to this article to disclose. The authors have no financial relationships relevant to this article to disclose.

Figures

Figure 1
Figure 1
Odds ratio (95% confidence interval) for the association between overweight/obesity (OW) duration in childhood and high risk of obstructive sleep apnoea in adulthood. The model was adjusted for baseline age, sex, race, education, adult OW status, leisure-time physical activity, follow-up years and time-dependent regular alcohol consumption and smoking status. * <0.05 compared with the never OW group.
See this image and copyright information in PMC

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