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Randomized Controlled Trial
. 2016 Jan;18(1):6-9.
doi: 10.7499/j.issn.1008-8830.2016.01.002.

[Efficacy of volume-targeted ventilation for the treatment of neonatal respiratory distress syndrome]

[Article in Chinese]
Chen-Zhou Liu  1 , Bi-Yin Huang, Bao-Ying Tan, Hao-Feng Guan, Xiao-Hui Xu, Qing-Yun Guo
Affiliations
Randomized Controlled Trial

[Efficacy of volume-targeted ventilation for the treatment of neonatal respiratory distress syndrome]

[Article in Chinese]
Chen-Zhou Liu et al. Zhongguo Dang Dai Er Ke Za Zhi. 2016 Jan.

Abstract
in English, Chinese

Objective: To investigate the efficacy of volume-targeted ventilation (VTV) for the treatment of neonatal respiratory distress syndrome (NRDS).

Methods: Fifty-two neonates with NRDS between August 2013 and August 2015 were randomly divided into two groups: VTV and pressure-controlled ventilation (PCV) (n=26 each ). A/C+Vc+ ventilation model was applied in the VTV group, and A/C+PCV ventilation model was applied in the PCV group. Arterial blood gas analysis was performed at 6, 24, and 48 hours after ventilation. The following parameters were observed: time of invasive ventilation, duration of oxygen therapy, mortality, and the incidence rates of hypocapnia, pneumothorax, ventilator-associated pneumonia (VAP), grade III-IV periventricular-intraventricular hemorrhage (PVH-IVH), periventricular leukomalacia (PVL), bronchopulmonary dysplasia (BPD), and retinopathy of prematurity (ROP).

Results: Compared with the PCV group, the VTV group had a significantly shorter time of invasive ventilation (P<0.05) and significantly lower incidence rates of hypocapnia, VAP, and PVL (P<0.05); however, there were no significant differences in the duration of oxygen therapy, mortality, and incidence rates of pneumothorax, grade III-IV PVH-IVH, BPD, and ROP.

Conclusions: VTV has a better efficacy than PCV in the treatment of NRDS, and is worthy of clinical promotion and application.

目的: 观察容量目标通气(VTV)治疗新生儿呼吸窘迫综合征(NRDS)的疗效。

方法: 将2013年8月至2015年8月52例NRDS患儿随机分为VTV组和压力控制通气(PCV)2组, 每组26例。VTV组采用A/C+Vc+模式, PCV组采用A/C+PCV模式。试验开始后6、24、48 h检查动脉血气分析, 观察有创通气时间、氧疗时间、病死率以及低碳酸血症、气胸、呼吸机相关性肺炎(VAP)、Ⅲ ~ Ⅳ级脑室周围-脑室内出血(PVH-IVH)、脑室周围白质软化(PVL)、支气管肺发育不良(BPD)、早产儿视网膜病变(ROP)的发生率。

结果: VTV组有创通气时间较PCV组短(P < 0.05), 低碳酸血症、VAP、PVL的发生率均低于PCV组(P < 0.05), 而两组吸氧时间、病死率、气胸和Ⅲ ~ Ⅳ级PVH-IVH以及BPD、ROP的发生率差异无统计学意义。

结论: VTV治疗NRDS的疗效优于PCV, 值得临床推广应用。

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References

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