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. 2016:876:511-519.
doi: 10.1007/978-1-4939-3023-4_64.

Characterizing Fluctuations of Arterial and Cerebral Tissue Oxygenation in Preterm Neonates by Means of Data Analysis Techniques for Nonlinear Dynamical Systems

Stefan Kleiser  1 , Marcin Pastewski  1 , Tharindi Hapuarachchi  2 , Cornelia Hagmann  3 , Jean-Claude Fauchère  3 , Ilias Tachtsidis  2 , Martin Wolf  1 , Felix Scholkmann  4
Affiliations

Characterizing Fluctuations of Arterial and Cerebral Tissue Oxygenation in Preterm Neonates by Means of Data Analysis Techniques for Nonlinear Dynamical Systems

Stefan Kleiser et al. Adv Exp Med Biol. 2016.

Erratum in

  • Erratum.
    Elwell CE, Leung TS, Harrison DK. Elwell CE, et al. Adv Exp Med Biol. 2016;876:E1-E2. doi: 10.1007/978-1-4939-3023-4_66. Adv Exp Med Biol. 2016. PMID: 27785776 Free PMC article. No abstract available.

Abstract

The cerebral autoregulatory state as well as fluctuations in arterial (SpO2) and cerebral tissue oxygen saturation (StO2) are potentially new relevant clinical parameters in preterm neonates. The aim of the present study was to test the investigative capabilities of data analysis techniques for nonlinear dynamical systems, looking at fluctuations and their interdependence. StO2, SpO2 and the heart rate (HR) were measured on four preterm neonates for several hours. The fractional tissue oxygenation extraction (FTOE) was calculated. To characterize the fluctuations in StO2, SpO2, FTOE and HR, two methods were employed: (1) phase-space modeling and application of the recurrence quantification analysis (RQA), and (2) maximum entropy spectral analysis (MESA). The correlation between StO2 and SpO2 as well as FTOE and HR was quantified by (1) nonparametric nonlinear regression based on the alternating conditional expectation (ACE) algorithm, and (2) the maximal information-based nonparametric exploration (MINE) technique. We found that (1) each neonate showed individual characteristics, (2) a ~60 min oscillation was observed in all of the signals, (3) the nonlinear correlation strength between StO2 and SpO2 as well as FTOE and HR was specific for each neonate and showed a high value for a neonate with a reduced health status, possibly indicating an impaired cerebral autoregulation. In conclusion, our data analysis framework enabled novel insights into the characteristics of hemodynamic and oxygenation changes in preterm infants. To the best of our knowledge, this is the first application of RQA, MESA, ACE and MINE to human StO2 data measured with near-infrared spectroscopy (NIRS).

Keywords: Autoregulation; Correlation analysis; Long term measurements; Near infrared spectroscopy; Spontaneous fluctuations.

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Figures

Fig. 64.1
Fig. 64.1
(a–d) Visualization of the analyzed signals (StO2, SpO2, FTOE and HR). (e–l) Frequency spectra obtained by MESA
Fig. 64.2
Fig. 64.2
(a, b) Correlation diagrams based on ACE nonparametric nonlinear regression. (c–j) Parameters obtained by RQA, MESA, ACE, MINE as well as the values for the median and variability
See this image and copyright information in PMC

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