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. 2016 Feb 16;114(4):395-400.
doi: 10.1038/bjc.2015.466. Epub 2016 Jan 19.

Validity of the online PREDICT tool in older patients with breast cancer: a population-based study

N A de Glas  1   2 , E Bastiaannet  1   2 , C C Engels  1 , A J M de Craen  2 , H Putter  3 , C J H van de Velde  1 , A Hurria  4 , G J Liefers  1 , J E A Portielje  5
Affiliations

Validity of the online PREDICT tool in older patients with breast cancer: a population-based study

N A de Glas et al. Br J Cancer. .

Abstract

Background: Predicting breast cancer outcome in older patients is challenging, as it has been shown that the available tools are not accurate in older patients. The PREDICT tool may serve as an alternative tool, as it was developed in a cohort that included almost 1800 women aged 65 years or over. The aim of this study was to assess the validity of the online PREDICT tool in a population-based cohort of unselected older patients with breast cancer.

Methods: Patients were included from the population-based FOCUS-cohort. Observed 5- and 10-year overall survival were estimated using the Kaplan-Meier method, and compared with predicted outcomes. Calibration was tested by composing calibration plots and Poisson Regression. Discriminatory accuracy was assessed by composing receiver-operator-curves and corresponding c-indices.

Results: In all 2012 included patients, observed and predicted overall survival differed by 1.7%, 95% confidence interval (CI)=-0.3-3.7, for 5-year overall survival, and 4.5%, 95% CI=2.3-6.6, for 10-year overall survival. Poisson regression showed that 5-year overall survival did not significantly differ from the ideal line (standardised mortality ratio (SMR)=1.07, 95% CI=0.98-1.16, P=0.133), but 10-year overall survival was significantly different from the perfect calibration (SMR=1.12, 95% CI=1.05-1.20, P=0.0004). The c-index for 5-year overall survival was 0.73, 95% CI=0.70-0.75, and 0.74, 95% CI=0.72-0.76, for 10-year overall survival.

Conclusions: PREDICT can accurately predict 5-year overall survival in older patients with breast cancer. Ten-year predicted overall survival was, however, slightly overestimated.

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Conflict of interest statement

Dr A Hurria received research support from Celgene and GSK. In addition, she worked as a consultant for GTx Inc. and Boehringer Inhelheim Pharmaceuticals. The remaining authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Calibration plot: observed vs predicted overall survival. P-values were calculated using Poisson regression.
Figure 2
Figure 2
ROC for 5- and 10-year overall survival. (A) Receiver-operating curve (ROC) for 5-year overall survival. The calculated area under the curve (AUC) was 0.73, 95% CI=0.70–0.75. (B) ROC for 10-year overall survival. The calculated AUC was 0.74, 95% CI=0.72–0.76.
See this image and copyright information in PMC

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