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Review
. 2015 Jun 10;56(1):E37-43.

Influenza vaccination in the elderly: why are the overall benefits still hotly debated?

C Trucchi  1 , C Paganino  1 , A Orsi  1 , D De Florentiis  1 , F Ansaldi  1
Affiliations
Review

Influenza vaccination in the elderly: why are the overall benefits still hotly debated?

C Trucchi et al. J Prev Med Hyg. .

Abstract

The exact magnitude of the benefit of influenza vaccine among elderly individuals is subject of considerable debated. Existing vaccine effectiveness estimates come mostly from observational studies, which may be biased because of difficulties in identifying and adjusting for confounders. In this paper, we examine the potential sources of bias in observational studies of influenza vaccine effectiveness in the elderly and we discuss available evidence regarding the efficacy and effectiveness of licensed influenza vaccines. Although several methodological criticisms among the available analyses on seasonal vaccines for elderly were identified, overall seasonal influenza vaccines showed relevant efficacy/effectiveness in reducing the risk of influenza and its complications in the elderly, considering different measure of outcome.

Keywords: Influenza vaccine; Vaccine effectiveness; Vaccine efficacy.

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Figures

Fig. 1.
Fig. 1.
Available estimates of influenza vaccine efficacy and effectiveness against lab-confirmed influenza in adults aged 50 years and older obtained by meta-analyses.
See this image and copyright information in PMC

References

    1. Schanzer DL, Tam TW, Langley JM, et al. Influenza-attributable deaths, Canada 1990-1999. Epidemiol Infect. 2007;135:1109–1116. - PMC - PubMed
    1. Thompson WW, Shay DK, Weintraub E, et al. Influenzaassociated hospitalizations in the United States. JAMA. 2004;292:1333–1340. - PubMed
    1. Vaccines against influenza WHO position paper – November 2012. Wkly Epidemiol Rec. 2012;87:461–476. - PubMed
    1. Fireman B, Lee J, Lewis N, et al. Influenza vaccination and mortality: differentiating vaccine effects from bias. Am J Epidemiol. 2009;170:650–656. - PMC - PubMed
    1. Jackson LA, Jackson ML, Nelson JC, et al. Evidence of bias in estimates of influenza vaccine effectiveness in seniors. Int J Epidemiol. 2006;35:337–344. - PubMed

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