Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Jan 21;374(3):279-80.
doi: 10.1056/NEJMe1515512.

Exacting Requirements for Development of the Egg

Jurrien Dean  1
Affiliations
Comment

Exacting Requirements for Development of the Egg

Jurrien Dean. N Engl J Med. .

Abstract

The hallmark of successful human reproduction is the fusion between a haploid spermatozoon and a metaphase II oocyte. The generation of such an oocyte involves a series of steps whereby germinal-vesicle oocytes (in which the nuclei are intact) at prophase I are stimulated to resume meiosis and mature to metaphase II, a sequence of events that prepares the oocyte for fertilization. Meiosis in mammalian females entails two reductive divisions of DNA to produce ovulated oocytes that can be fertilized in the oviduct (Figure 1). In the first meiotic division, replicated chromosomes condense and attach to kinetochores through their centromeres to . . .

PubMed Disclaimer

Comment on

  • Mutations in TUBB8 and Human Oocyte Meiotic Arrest.
    Feng R, Sang Q, Kuang Y, Sun X, Yan Z, Zhang S, Shi J, Tian G, Luchniak A, Fukuda Y, Li B, Yu M, Chen J, Xu Y, Guo L, Qu R, Wang X, Sun Z, Liu M, Shi H, Wang H, Feng Y, Shao R, Chai R, Li Q, Xing Q, Zhang R, Nogales E, Jin L, He L, Gupta ML Jr, Cowan NJ, Wang L. Feng R, et al. N Engl J Med. 2016 Jan 21;374(3):223-32. doi: 10.1056/NEJMoa1510791. N Engl J Med. 2016. PMID: 26789871 Free PMC article.

LinkOut - more resources