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Comment
. 2016 Jan 19;44(1):16-18.
doi: 10.1016/j.immuni.2015.12.016.

HIV and Tfh Cells: Circulating New Ideas to Identify and Protect

Ann Chahroudi  1 , Guido Silvestri  2
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HIV and Tfh Cells: Circulating New Ideas to Identify and Protect

Ann Chahroudi et al. Immunity. .
Free article

Abstract

T follicular helper (Tfh) cells provide crucial support to antigen-specific B cells. In this issue of Immunity, Schultz et al. (2016) report that circulating IL-21-producing CD4(+) T cells are phenotypically, transcriptionally, and functionally similar to lymphoid Tfh cells and that such HIV-specific Tfh cells were increased in RV144 trial vaccine recipients.

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