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Comment
. 2016 Jan 19;44(1):18-20.
doi: 10.1016/j.immuni.2015.12.019.

Myelopoiesis Reloaded: Single-Cell Transcriptomics Leads the Way

Joachim L Schultze  1 , Marc Beyer  2
Affiliations
Free article
Comment

Myelopoiesis Reloaded: Single-Cell Transcriptomics Leads the Way

Joachim L Schultze et al. Immunity. .
Free article

Abstract

Lineage commitment during myelopoiesis has been linked to late-stage progenitors with multi-lineage potential. In a recent issue of Cell, Paul et al. (2015) now suggest a much earlier commitment toward distinct lineages even prior to the common myeloid progenitor state.

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  • Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors.
    Paul F, Arkin Y, Giladi A, Jaitin DA, Kenigsberg E, Keren-Shaul H, Winter D, Lara-Astiaso D, Gury M, Weiner A, David E, Cohen N, Lauridsen FK, Haas S, Schlitzer A, Mildner A, Ginhoux F, Jung S, Trumpp A, Porse BT, Tanay A, Amit I. Paul F, et al. Cell. 2015 Dec 17;163(7):1663-77. doi: 10.1016/j.cell.2015.11.013. Epub 2015 Nov 25. Cell. 2015. PMID: 26627738

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