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Review
. 2016 Jan 21;529(7586):336-43.
doi: 10.1038/nature17042.

Antibacterial drug discovery in the resistance era

Eric D Brown  1   2 , Gerard D Wright  1   2
Affiliations
Review

Antibacterial drug discovery in the resistance era

Eric D Brown et al. Nature. .

Abstract

The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians, researchers, policymakers, politicians and the public at large. The evolution and widespread distribution of antibiotic-resistance elements in bacterial pathogens has made diseases that were once easily treatable deadly again. Unfortunately, accompanying the rise in global resistance is a failure in antibacterial drug discovery. Lessons from the history of antibiotic discovery and fresh understanding of antibiotic action and the cell biology of microorganisms have the potential to deliver twenty-first century medicines that are able to control infection in the resistance era.

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References

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