Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Feb 2;113(5):1121-3.
doi: 10.1073/pnas.1524017113. Epub 2016 Jan 20.

Constant molecular aging rates vs. the exponential acceleration of mortality

Caleb E Finch  1 , Eileen M Crimmins  2
Affiliations
Comment

Constant molecular aging rates vs. the exponential acceleration of mortality

Caleb E Finch et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Comment on

  • Protein carbamylation is a hallmark of aging.
    Gorisse L, Pietrement C, Vuiblet V, Schmelzer CE, Köhler M, Duca L, Debelle L, Fornès P, Jaisson S, Gillery P. Gorisse L, et al. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1191-6. doi: 10.1073/pnas.1517096113. Epub 2015 Dec 28. Proc Natl Acad Sci U S A. 2016. PMID: 26712018 Free PMC article.

References

    1. Gorisse L, et al. Protein carbamylation is a hallmark of aging. Proc Natl Acad Sci USA. 2016;113:1191–1196. - PMC - PubMed
    1. Stark GR, Stein WH, Moore S. Reactions of the cyanate present in aqueous urea with amino acids and proteins. J Biol Chem. 1960;235(11):3177–3181.
    1. Hawkins CL. Role of cyanate in the induction of vascular dysfunction during uremia: More than protein carbamylation? Kidney Int. 2014;86(5):875–877. - PubMed
    1. Sell DR, et al. Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence. Proc Natl Acad Sci USA. 1996;93(1):485–490. - PMC - PubMed
    1. Sell DR, et al. Glucosepane is a major protein cross-link of the senescent human extracellular matrix. Relationship with diabetes. J Biol Chem. 2005;280(13):12310–12315. - PubMed

Publication types

LinkOut - more resources