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. 2014 Oct-Dec;40(4):249-52.
doi: 10.12865/CHSJ.40.04.03. Epub 2014 Dec 14.

Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients

V Pădureanu  1 , Ioana StreaȚă  1 , M Ioana  1 , V Șurlin  1 , E F Georgescu  1 , Cristina Mărginean  1 , A Săftoiu  1
Affiliations

Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients

V Pădureanu et al. Curr Health Sci J. 2014 Oct-Dec.

Abstract

Purpose: To determine whether single nucleotide polymorphism (SNP) of inducible nitric oxide synthase (iNOS) is involved in susceptibility for acute pancreatitis.

Material and methods: Genomic DNA was extracted from blood samples collected from cases of acute pancreatitis (n=110) and normal population controls frequency matched for age and sex (n=232). iNOS - 2087A>G polymorphism was genotyped using TaqMan allelic discrimination assays. The association of the genetic polymorphism with clinical and pathological data of the patients was evaluated.

Results: We have found no significant statistical association between this polymorphism and an increased risk of developing acute pancreatitis.

Conclusion: In Romanian population, the risk of developing acute pancreatitis is not increased by the presence of iNOS-2087A>G polymorphism.

Keywords: acute pancreatitis; genotype; iNOS; polymorphism.

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References

    1. Ozhan G, Sari FM, Vefai M, Yanar HT, Alpertunga B. Acute pancreatitis is associated with Ser608Leu iNOS polymorphism. Folia Biologica. 2012;58(6):256–260. - PubMed
    1. Powell JJ, Fearon KC, Siriwardena AK, Ross JA. Evidence against a role for polymorphisms at tumor necrosis factor, interleukin-1 and interleukin-1 receptor antagonist gene loci in the regulation of disease severity in acute pancreatitis. Surgery. 2001;129(5):633–640. - PubMed
    1. Goldie AS, Fearon KC, Ross JA, Barclay GR, Jackson RE, Grant IS, et al. Natural cytokine antagonists and endogenous antiendotoxin core antibodies in sepsis syndrome. The Sepsis Intervention Group. JAMA. 1995;274(2):172–177. - PubMed
    1. He C, Zhang L, Shi W, Liang X, Ye Z, Zhang B, et al. Coupled plasma filtration adsorption combined with continuous veno-venous hemofiltration treatment in patients with severe acute pancreatitis. Journal of Clinical Gastroenterology. 2013;47(1):62–68. - PubMed
    1. Papachristou GI. Prediction of severe acute pancreatitis: current knowledge and novel insights. World journal of gastroenterology : WJG. 2008;14(41):6273–6275. - PMC - PubMed

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