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Review
. 2015 Dec;7(12):2172-80.
doi: 10.3978/j.issn.2072-1439.2015.10.70.

The total artificial heart

Jason A Cook  1 , Keyur B Shah  1 , Mohammed A Quader  1 , Richard H Cooke  1 , Vigneshwar Kasirajan  1 , Kris K Rao  1 , Melissa C Smallfield  1 , Inna Tchoukina  1 , Daniel G Tang  1
Affiliations
Review

The total artificial heart

Jason A Cook et al. J Thorac Dis. 2015 Dec.

Erratum in

Abstract

The total artificial heart (TAH) is a form of mechanical circulatory support in which the patient's native ventricles and valves are explanted and replaced by a pneumatically powered artificial heart. Currently, the TAH is approved for use in end-stage biventricular heart failure as a bridge to heart transplantation. However, with an increasing global burden of cardiovascular disease and congestive heart failure, the number of patients with end-stage heart failure awaiting heart transplantation now far exceeds the number of available hearts. As a result, the use of mechanical circulatory support, including the TAH and left ventricular assist device (LVAD), is growing exponentially. The LVAD is already widely used as destination therapy, and destination therapy for the TAH is under investigation. While most patients requiring mechanical circulatory support are effectively treated with LVADs, there is a subset of patients with concurrent right ventricular failure or major structural barriers to LVAD placement in whom TAH may be more appropriate. The history, indications, surgical implantation, post device management, outcomes, complications, and future direction of the TAH are discussed in this review.

Keywords: Total artificial heart (TAH).

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Conflict of interest statement

Conflicts of Interest: Shah: Research Grants from Thoratec Corp; Tang: Principal Investigator for Syncardia Systems, HeartWare Corp and Sunshine Heart; Kasirajan: Principal Investigator for Thoratec Corp and Syncardia Systems.

Figures

Figure 1
Figure 1
Syncardia Freedom Driver: compact external pneumatic pump which enables patients to be discharged from the hospital.
Figure 2
Figure 2
Syncardia CardioWest-t Total Artificial Heart: orthotopic artificial heart which replaces the ventricles and valves of the native heart. Used with permission from Syncardia Systems, Inc., Communications Department.
See this image and copyright information in PMC

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