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Case Reports
. 2015 Sep 30;2(4):106-8.
doi: 10.1016/j.idcr.2015.09.007. eCollection 2015.

Trichosporon fungemia in a pediatric patient with acute lymphoblastic leukemia

Luke Maxfield  1 , Juliana J Matthews  1 , David Ryan Ambrosetti  1 , Issa E Ephtimios  1
Affiliations
Case Reports

Trichosporon fungemia in a pediatric patient with acute lymphoblastic leukemia

Luke Maxfield et al. IDCases. .

Abstract

Trichosporon fungemia is a life-threatening opportunistic infection that is increasing in frequency. Invasive disease occurs almost exclusively in immunocompromised hosts, particularly in neutropenic adults with hematological malignancies and uncommonly in children. We report the case of a pediatric patient where disseminated trichosporonosis progressed while on micafungin, between treatments with voriconazole and amphotericin B, demonstrating the difficulty with and importance of prolonged and continuous treatment.

Keywords: Acute lymphoblastic leukemia; Antifungal resistance; Fungemia; Trichosporon.

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Figures

Fig. 1
Fig. 1
Maculopapular lesions on the extremities of a pediatric patient with disseminated trichosporonosis.
Fig. 2
Fig. 2
PAS staining at 600 times magnification from skin lesion, which revealed budding yeasts and rare hyphae adjacent to fat.
Fig. 3
Fig. 3
PAS stained at 600 times magnification revealing fungal elements of patient with disseminated Trichosporon asahii infection, including true hyphae, pseudohyphae, arthroconidia, and blastospores.
See this image and copyright information in PMC

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