Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Jun;51(6):520-30.
doi: 10.1007/s00535-016-1161-9. Epub 2016 Jan 21.

The role of microRNA in esophageal squamous cell carcinoma

Kazuto Harada  1 , Yoshifumi Baba  1 , Takatsugu Ishimoto  1 , Hironobu Shigaki  1 , Keisuke Kosumi  1 , Naoya Yoshida  1 , Masayuki Watanabe  2 , Hideo Baba  3
Affiliations
Review

The role of microRNA in esophageal squamous cell carcinoma

Kazuto Harada et al. J Gastroenterol. 2016 Jun.

Abstract

MicroRNAs (miRNA) are 22-nucleotide non-coding RNAs that post-transcriptionally regulate gene expression by base pairing to partially complementary sequences in the 3'-untranslated region of their target messenger RNA. Altered miRNA expression also changes the expression of oncogenes and tumor suppressors, affecting the proliferation, apoptosis, motility and invasibility of gastrointestinal cancer cells, including the cells of esophageal squamous cell carcinoma (ESCC). It has been suggested that various miRNA expression profiles may provide useful biomarkers and therapeutic targets, but to date few studies have been published on the role of miRNA in ESCC. In this review we summarize the identification and characterization of miRNAs involved in ESCC and discuss their potential as biomarkers and therapeutic targets.

Keywords: Biomarkers; Esophageal squamous cell carcinoma; MicroRNA; Review; Therapeutic targets.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nat Rev Genet. 2004 Jul;5(7):522-31 - PubMed
    1. Neoplasma. 2015 ;62(3):384-90 - PubMed
    1. Oncol Rep. 2013 Jan;29(1):169-76 - PubMed
    1. Clin Cancer Res. 2011 May 1;17(9):3029-38 - PubMed
    1. Int J Oncol. 2011 Apr;38(4):1013-22 - PubMed

MeSH terms

LinkOut - more resources