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Review
. 2016 Apr;15(4):275-92.
doi: 10.1038/nrd.2015.21. Epub 2016 Jan 22.

From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery

William A Banks  1
Affiliations
Review

From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery

William A Banks. Nat Rev Drug Discov. 2016 Apr.

Abstract

One of the biggest challenges in the development of therapeutics for central nervous system (CNS) disorders is achieving sufficient blood-brain barrier (BBB) penetration. Research in the past few decades has revealed that the BBB is not only a substantial barrier for drug delivery to the CNS but also a complex, dynamic interface that adapts to the needs of the CNS, responds to physiological changes, and is affected by and can even promote disease. This complexity confounds simple strategies for drug delivery to the CNS, but provides a wealth of opportunities and approaches for drug development. Here, I review some of the most important areas that have recently redefined the BBB and discuss how they can be applied to the development of CNS therapeutics.

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References

    1. Endocrinology. 2009 Jul;150(7):3083-91 - PubMed
    1. J Neurovirol. 2004 Aug;10(4):223-32 - PubMed
    1. Peptides. 1999 Nov;20(11):1341-5 - PubMed
    1. Biochem Biophys Res Commun. 2009 Dec 18;390(3):368-71 - PubMed
    1. Life Sci. 2003 Apr 25;72(23):2581-90 - PubMed

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