Stop and Think about Basal Ganglia Functional Organization: The Pallido-Striatal "Stop" Route

Marc Deffains¹, Liliya Iskhakova¹, Hagai Bergman²

Affiliations

¹ Department of Medical Neurobiology, Institute of Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, 91904, Israel.
² Department of Medical Neurobiology, Institute of Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, 91904, Israel; Department of Neurosurgery, Hadassah Medical Center, Jerusalem, 12000, Israel. Electronic address: hagaibe@ekmd.huji.ac.il.

PMID: 26796685
DOI: 10.1016/j.neuron.2016.01.003

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Stop and Think about Basal Ganglia Functional Organization: The Pallido-Striatal "Stop" Route

Marc Deffains et al. Neuron. 2016.

Free article

. 2016 Jan 20;89(2):237-9.

doi: 10.1016/j.neuron.2016.01.003.

Authors

Marc Deffains¹, Liliya Iskhakova¹, Hagai Bergman²

Affiliations

¹ Department of Medical Neurobiology, Institute of Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, 91904, Israel.
² Department of Medical Neurobiology, Institute of Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, 91904, Israel; Department of Neurosurgery, Hadassah Medical Center, Jerusalem, 12000, Israel. Electronic address: hagaibe@ekmd.huji.ac.il.

PMID: 26796685
DOI: 10.1016/j.neuron.2016.01.003

Abstract

The "arkypallidal" neurons of the globus pallidus (external segment) emit feedback GABAergic projections to the striatum. In this issue of Neuron, Mallet et al. (2016) show that "arkypallidal" neurons provide a Stop signal, suppressing the development of Go-related striatal activity.

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Arkypallidal Cells Send a Stop Signal to Striatum.
Mallet N, Schmidt R, Leventhal D, Chen F, Amer N, Boraud T, Berke JD. Mallet N, et al. Neuron. 2016 Jan 20;89(2):308-16. doi: 10.1016/j.neuron.2015.12.017. Neuron. 2016. PMID: 26777273 Free PMC article.

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Stop and Think about Basal Ganglia Functional Organization: The Pallido-Striatal "Stop" Route

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Stop and Think about Basal Ganglia Functional Organization: The Pallido-Striatal "Stop" Route

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