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. 2015 Oct 19;3(4):343-5.
doi: 10.1002/sm2.93. eCollection 2015 Dec.

Painful Ejaculation with Cyclobenzaprine: A Case Report and Literature Review

Molly B Kraus  1 , Christopher S Wie  1 , Andrew W Gorlin  1 , Eric S Wisenbaugh  2 , David M Rosenfeld  1
Affiliations

Painful Ejaculation with Cyclobenzaprine: A Case Report and Literature Review

Molly B Kraus et al. Sex Med. .

Abstract

Introduction: Sexual dysfunction is a well-known side effect of antidepressants. Painful ejaculation is a rare side effect that has been reported with the use of some psychiatric drugs such as triclyclic antidepressants. Cyclobenzaprine is a muscle relaxant that is structurally similar to tricyclic antidepressants. It is the most commonly prescribed muscle relaxant in the United States and accounts for 18% of all prescriptions written for chronic back pain.

Methods: A 55-year-old man was referred to our pain medicine clinic for evaluation and treatment of pain with ejaculation.

Main outcome measure: The main outcome measure was to review the current published literature and case reports on painful ejaculation from medication use, in particular tricyclic antidepressants.

Results: After discontinuation of cyclobenzaprine, our patient's sexual dysfunction resolved. This result was consistent with the literature reviewed on the topic.

Conclusion: Painful ejaculation is likely an underreported side effect of tricyclic antidepressants and cyclobenzaprine use. Fortunately, these symptoms are reversible and discontinuation of these medications is typically an effective cure. K raus MB , W ie CS , G orlin AW , W isenbaugh ES , and R osenfeld DM . Painful ejaculation with cyclobenzaprine: A case report and literature review. S ex M ed 2015;3:343-345.

Keywords: Cyclobenzaprine; Ejaculation; Orgasmic Disorder; Sexual Dysfunction.

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Figures

Figure 1
Figure 1
The chemical structures of cyclobenzaprine, amitripyline, and imipramine, highlighting the similarities.
See this image and copyright information in PMC

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