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. 2015 Oct-Dec;7(4):142-5.

2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors

D A Babkov  1 , M P Paramonova  1 , A A Ozerov  1 , A L Khandazhinskaya  2 , R Snoeck  3 , G Andrei  3 , M S Novikov  1
Affiliations

2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors

D A Babkov et al. Acta Naturae. 2015 Oct-Dec.

Abstract

A series of novel uracil derivatives, bearing N-(4-phenoxyphenyl)acetamide moiety at N3 of a pyrimidine ring, has been synthesized. Their antiviral activity has been evaluated. It has been found that the novel compounds possess high inhibitory activity against replication of human cytomegalovirus (AD-169 and Davis strains) in HEL cell cultures. In addition, some of the derivatives proved to be inhibitory against varicella zoster virus.

Keywords: antiviral activity; human cytomegalovirus; synthesis; uracil derivatives.

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