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Review
. 2015:2015:985071.
doi: 10.1155/2015/985071. Epub 2015 Dec 21.

Efficacy and Safety of Topical Timolol Eye Drops in the Treatment of Myopic Regression after Laser In Situ Keratomileusis: A Systematic Review and Meta-Analysis

Xiaochen Wang  1 , Guiqiu Zhao  1 , Jing Lin  1 , Nan Jiang  1 , Qian Wang  1 , Qiang Xu  1
Affiliations
Review

Efficacy and Safety of Topical Timolol Eye Drops in the Treatment of Myopic Regression after Laser In Situ Keratomileusis: A Systematic Review and Meta-Analysis

Xiaochen Wang et al. J Ophthalmol. 2015.

Abstract

Aims. The aim of this study was to assess the efficacy and safety of timolol in the treatment of myopic regression after laser in situ keratomileusis (LASIK). Methods. We searched MEDLINE, CENTRAL, EMBASE, China National Knowledge Infrastructure (CNKI), and Chinese Biological Medicine (CBM) from the inception to July 2015 for relevant randomized controlled trials that examined timolol therapy for myopic regression. The methodological quality of the studies included was assessed using the Revman 5.3 software. Results. We included six clinical trials involving 483 eyes in this review, including 246 eyes in treated group and 237 eyes in controlled group. We observed statistically significant improvements on the postoperative SE in the 3 months. However, the change of CCT was not statistically different between the control group and the experimental group. There were fewer cases of IOP, UDVA, and CDVA in treated group having significant difference from the controlled group. Conclusions. Topical timolol could be an effective treatment for reduction of myopic regression especially the spherical errors after myopic LASIK. Further RCTs with larger sample sizes for these trials are warranted to determine the efficacy and limitation for myopic regression after LASIK.

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Figures

Figure 1
Figure 1
Flowchart of the trial selection process. RCT: randomized clinical trial.
Figure 2
Figure 2
(a) Risk of bias summary: authors' judgments about each risk of bias item for each included risk. (b) Risk of bias graph: authors' judgments about each risk of bias item presented as percentages across all included studies.
Figure 3
Figure 3
Forest plot comparing the spherical equivalent refraction in timolol and control groups. SD: standard deviation; IV: inverse variance; CI: confidence interval.
Figure 4
Figure 4
Comparison of central corneal thickness in patients with myopic regression after LASIK.
Figure 5
Figure 5
Intraocular pressure in timolol and controls groups.
Figure 6
Figure 6
Comparison of logMAR UDVA between the two groups in different time.
Figure 7
Figure 7
Comparison of logMAR CDVA between the two groups in two studies.
See this image and copyright information in PMC

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