Review
doi: 10.1017/s0317167100029796.
Altered gene expression in Alzheimer's disease brain tissue
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- PMID: 2680007
- DOI: 10.1017/s0317167100029796
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Review
Altered gene expression in Alzheimer's disease brain tissue
Can J Neurol Sci.
1989 Nov.
Abstract
We review the evidence for altered gene expression in Alzheimer's disease brain and identify alternative molecular approaches for isolating additional novel markers. One marker, pADHC-9, was isolated from a human hippocampal cDNA library by differential screening with AD and control cDNA probes. This clone hybridizes to a 2 Kb RNA which is increased 2 fold in AD hippocampus. The deduced amino acid sequence of pADHC-9 codes for a 52 kDAL protein similar to a testicular sulfated glycoprotein secreted by rat Sertoli cells. The normal function of this protein in brain and whether that function is altered in Alzheimer's disease is unknown.
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