Late Effects Surveillance Recommendations among Survivors of Childhood Hematopoietic Cell Transplantation: A Children's Oncology Group Report

Eric J Chow¹, Lynnette Anderson², K Scott Baker³, Smita Bhatia⁴, Gregory M T Guilcher⁵, Jennifer T Huang⁶, Wendy Pelletier⁵, Joanna L Perkins⁷, Linda S Rivard⁸, Tal Schechter⁹, Ami J Shah¹⁰, Karla D Wilson¹¹, Kenneth Wong¹², Satkiran S Grewal¹³, Saro H Armenian¹¹, Lillian R Meacham¹⁴, Daniel A Mulrooney¹⁵, Sharon M Castellino¹⁴

Affiliations

¹ Clinical Research and Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, Washington. Electronic address: ericchow@u.washington.edu.
² Department of Pediatric Hematology, Oncology, and Bone Marrow Transplant, Medical College of Wisconsin, Milwaukee, Wisconsin.
³ Clinical Research and Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, Washington.
⁴ Institute for Cancer Outcomes and Survivorship, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
⁵ Departments of Oncology and Paediatrics, Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.
⁶ Department of Dermatology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
⁷ Department of Cancer and Blood Disorders, Children's Hospital and Clinics of Minnesota, Minneapolis, Minnesota.
⁸ Department of Pediatric Hematology Oncology, Advocate Children's Hospital, Oak Lawn, Illinois.
⁹ Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
¹⁰ Division of Stem Cell Transplant and Regenerative Medicine, Lucile Packard Children's Hospital, Stanford University, Stanford, California.
¹¹ Department of Population Sciences, City of Hope National Medical Center, Duarte, California.
¹² Department of Radiation Oncology, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, California.
¹³ Department of Pediatrics, Baystate Children's Hospital, Tufts University School of Medicine, Springfield, Massachusetts.
¹⁴ Department of Pediatrics, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia.
¹⁵ Department of Oncology, St. Jude Children's Research Hospital, University of Tennessee Health Science Center, Memphis, Tennessee.

PMID: 26802323
PMCID: PMC4826622
DOI: 10.1016/j.bbmt.2016.01.023

Review

Late Effects Surveillance Recommendations among Survivors of Childhood Hematopoietic Cell Transplantation: A Children's Oncology Group Report

Eric J Chow et al. Biol Blood Marrow Transplant. 2016 May.

. 2016 May;22(5):782-95.

doi: 10.1016/j.bbmt.2016.01.023. Epub 2016 Jan 21.

Authors

Affiliations

¹ Clinical Research and Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, Washington. Electronic address: ericchow@u.washington.edu.
² Department of Pediatric Hematology, Oncology, and Bone Marrow Transplant, Medical College of Wisconsin, Milwaukee, Wisconsin.
³ Clinical Research and Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, University of Washington, Seattle, Washington.
⁴ Institute for Cancer Outcomes and Survivorship, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
⁵ Departments of Oncology and Paediatrics, Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.
⁶ Department of Dermatology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
⁷ Department of Cancer and Blood Disorders, Children's Hospital and Clinics of Minnesota, Minneapolis, Minnesota.
⁸ Department of Pediatric Hematology Oncology, Advocate Children's Hospital, Oak Lawn, Illinois.
⁹ Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
¹⁰ Division of Stem Cell Transplant and Regenerative Medicine, Lucile Packard Children's Hospital, Stanford University, Stanford, California.
¹¹ Department of Population Sciences, City of Hope National Medical Center, Duarte, California.
¹² Department of Radiation Oncology, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, California.
¹³ Department of Pediatrics, Baystate Children's Hospital, Tufts University School of Medicine, Springfield, Massachusetts.
¹⁴ Department of Pediatrics, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia.
¹⁵ Department of Oncology, St. Jude Children's Research Hospital, University of Tennessee Health Science Center, Memphis, Tennessee.

PMID: 26802323
PMCID: PMC4826622
DOI: 10.1016/j.bbmt.2016.01.023

Abstract

Hematopoietic cell transplantation (HCT) is an important curative treatment for children with high-risk hematologic malignancies, solid tumors, and, increasingly, nonmalignant diseases. Given improvements in care, there are a growing number of long-term survivors of pediatric HCT. Compared with childhood cancer survivors who did not undergo transplantation, HCT survivors have a substantially increased burden of serious chronic conditions and impairments involving virtually every organ system and overall quality of life. This likely reflects the joint contributions of pretransplantation treatment exposures and organ dysfunction, the transplantation conditioning regimen, and any post-transplantation graft-versus-host disease (GVHD). In response, the Children's Oncology Group (COG) has created long-term follow-up guidelines (www.survivorshipguidelines.org) for survivors of childhood, adolescent, and young adult cancer, including those who were treated with HCT. Guideline task forces, consisting of HCT specialists, other pediatric oncologists, radiation oncologists, organ-specific subspecialists, nurses, social workers, other health care professionals, and patient advocates systematically reviewed the literature with regards to late effects after childhood cancer and HCT since 2002, with the most recent review completed in 2013. For the most recent review cycle, over 800 articles from the medical literature relevant to childhood cancer and HCT survivorship were reviewed, including 586 original research articles. Provided herein is an organ system-based overview that emphasizes the most relevant COG recommendations (with accompanying evidence grade) for the long-term follow-up care of childhood HCT survivors (regardless of current age) based on a rigorous review of the available evidence. These recommendations cover both autologous and allogeneic HCT survivors, those who underwent transplantation for nonmalignant diseases, and those with a history of chronic GVHD.

Keywords: Childhood; Guideline; Hematopoietic cell transplantation; Late effects; Surveillance; Survivor.

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Conflict of interest statement

The authors declare no conflicts of interests, including no competing financial interests

References

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Late Effects Surveillance Recommendations among Survivors of Childhood Hematopoietic Cell Transplantation: A Children's Oncology Group Report

Affiliations

Late Effects Surveillance Recommendations among Survivors of Childhood Hematopoietic Cell Transplantation: A Children's Oncology Group Report

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

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