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Comment
. 2016 May;22(4):247-8.
doi: 10.1111/odi.12445. Epub 2016 Feb 15.

On the origin of blood cells--hematopoiesis revisited

Éva Mezey  1
Affiliations
Comment

On the origin of blood cells--hematopoiesis revisited

Éva Mezey. Oral Dis. 2016 May.
No abstract available

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Figures

Figure 1
Figure 1
A. Conventional depiction of human hematopoiesis The oligopotent HSC (hematopoietic stem cell) is at the top of the pyramid. (This cell can reproduce itself and differentiate into all lineages.) MPP cells are multipotent progenitors with limited self-renewal and multilineage reconstitution capacity. They give rise to the common myeloid progenitor (CMP) and the common lymphoid progenitor (CLP) that generates lymphocytes (Ly). CMPs differentiate into megakaryocyte (Mk)/erythroid (Ery) progenitor cells (MEPs) and granulocyte (Gr)/ monocyte (Mon) progenitors (GMP). According to this hypothesis, multipotent, oligopotent and then lineage-restricted cells are derived gradually, one after another, from HSCs. B. New hypothesis of human adult hematopoiesis The oligopotent HSC first gives rise to the Mk lineage and multipotent MPP cells. The latter give rise to three unipotent lineages: the erythroid (Ery), myeloid (My) and the monocytic/lymphoid (Mono-Ly) lineages.
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