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Multicenter Study
. 2016 Apr;22(4):387.e1-387.e4.
doi: 10.1016/j.cmi.2015.11.024. Epub 2016 Jan 20.

Healthcare-associated Crimean-Congo haemorrhagic fever in Turkey, 2002-2014: a multicentre retrospective cross-sectional study

H Leblebicioglu  1 , M Sunbul  2 , R Guner  3 , H Bodur  4 , C Bulut  5 , F Duygu  6 , N Elaldi  7 , G Cicek Senturk  8 , Z Ozkurt  9 , G Yilmaz  10 , T E Fletcher  11 , N J Beeching  12
Affiliations
Multicenter Study

Healthcare-associated Crimean-Congo haemorrhagic fever in Turkey, 2002-2014: a multicentre retrospective cross-sectional study

H Leblebicioglu et al. Clin Microbiol Infect. 2016 Apr.

Abstract

Healthcare-related transmission of Crimean-Congo haemorrhagic fever (CCHF) is a well-recognized hazard. We report a multicentre retrospective cross-sectional study undertaken in Turkey in 2014 in nine hospitals, regional reference centres for CCHF, covering the years 2002 to 2014 inclusive. Data were systematically extracted from charts of all personnel with a reported health care injury/accident related to CCHF. Blood samples were tested for CCHF IgM/IgG by enzyme-linked immunosorbent assay and/or viral nucleic acid detection by PCR after the injury. Fifty-one healthcare-related exposures were identified. Twenty-five (49%) of 51 resulted in laboratory-confirmed infection, with a 16% (4/25) overall mortality. The main route of exposure was needlestick injury in 32/51 (62.7%). A potential benefit of post-exposure prophylaxis with ribavirin was identified.

Keywords: Crimean-Congo haemorrhagic fever; healthcare associated; infection prevention and control; ribavirin; viral haemorrhagic fever.

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Figures

Fig. 1
Fig. 1
(a) Exposure and outcomes of 51 CCHF HCW exposures, related to mode of exposure and laboratory confirmation. (b) Outcome of CCHF HCW exposures stratified by administration of PEP. CCHF, Crimean-Congo haemorrhagic fever; HCW, healthcare worker; PEP, post-exposure prophylaxis.
See this image and copyright information in PMC

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