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Case Reports
. 2016 May;63(5):1733-5.
doi: 10.1002/hep.28470. Epub 2016 Mar 10.

Variceal Hemorrhage in a Patient With Hepatitis C Virus Cirrhosis in Whom Liver Synthetic Function had Normalized After Viral Elimination

Jordan Sack  1 , Guadalupe Garcia-Tsao  2   3
Affiliations
Case Reports

Variceal Hemorrhage in a Patient With Hepatitis C Virus Cirrhosis in Whom Liver Synthetic Function had Normalized After Viral Elimination

Jordan Sack et al. Hepatology. 2016 May.
No abstract available

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Figures

Figure 1
Figure 1
Timeline of laboratory tests and sequence of events. Albumin (g/dL); AST (U/L); Platelet count (×103/μL); Tx1 = initiation of first course of PEG/RBV (48 weeks); Tx2 = initiation of second course of PEG/RBV (72 weeks); EVH = esophageal variceal hemorrhage. After attaining sustained virological response, liver enzymes normalized as did liver synthetic function (serum albumin, INR). Platelet count decreased with each antiviral therapy but also had a tendency to improve (perhaps also as a reflection of improved liver synthetic function).
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References

    1. Lens S, Rincon D, Garcia-Retortillo M, et al. Association between severe portal hypertension and risk of liver decompensation in patients with hepatitis C, regardless of response to antiviral therapy. Clin Gastroenterol Hepatol. 2015;13:1846–53. - PubMed
    1. Nagula S, Jain D, Groszmann RJ, Garcia-Tsao G. Histological-hemodynamic correlation in cirrhosis-a histological classification of the severity of cirrhosis. J Hepatol. 2006;44:111–7. - PubMed
    1. Garcia-Tsao G, Friedman S, Iredale J, Pinzani M. Now There Are Many (Stages) Where Before There Was One: In Search of a Pathophysiological Classification of Cirrhosis. Hepatology. 2010;51:1445–49. - PMC - PubMed
    1. Monitoring Patients Who Are Starting Hepatitis C Treatment, are on Treatment, or have Completed Therapy. AASLD and IDSA guidance recommendations. http://www.hcvguidelines.org.

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