The Role of Immune Cells in Chronic HBV Infection

doi:10.14218/JCTH.2015.00026

Review

. 2015 Dec 28;3(4):277-83.

doi: 10.14218/JCTH.2015.00026. Epub 2015 Dec 15.

The Role of Immune Cells in Chronic HBV Infection

Hai-Jun Li¹, Nai-Cui Zhai¹, Hong-Xiao Song¹, Yang Yang¹, An Cui¹, Tian-Yang Li¹, Zheng-Kun Tu¹

Affiliations

PMID: 26807384
PMCID: PMC4721896
DOI: 10.14218/JCTH.2015.00026

Review

The Role of Immune Cells in Chronic HBV Infection

Hai-Jun Li et al. J Clin Transl Hepatol. 2015.

. 2015 Dec 28;3(4):277-83.

doi: 10.14218/JCTH.2015.00026. Epub 2015 Dec 15.

Authors

Hai-Jun Li¹, Nai-Cui Zhai¹, Hong-Xiao Song¹, Yang Yang¹, An Cui¹, Tian-Yang Li¹, Zheng-Kun Tu¹

Affiliation

¹ Department of Translational Medicine, The First Hospital, Jilin University, Changchun, Jilin, China.

PMID: 26807384
PMCID: PMC4721896
DOI: 10.14218/JCTH.2015.00026

Abstract

Hepatitis B virus (HBV) infection is a major cause of chronic liver diseases that may progress to liver cirrhosis and hepatocellular carcinoma. Host immune responses are important factors that determine whether HBV infection is cleared or persists. After infection, viral replication occurs inside hepatocytes, and the secretion of infectious virions can take place at high rates for decades. Consequently, HBV DNA and viral proteins, like HBV early antigen (HBeAg) and HBV surface antigen (HBsAg), can be easily detected in serum. Chronic infection with HBV is the result of an ineffective antiviral immune response towards the virus. In this review, we discuss the role of immune cells in chronic HBV infection.

Keywords: CD8+ T cells; Hepatitis B virus; Immune cells; Natural killer cells.

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Conflict of interest statement

Conflict of interest: None.

Figures

**Fig. 1.. Natural killer cells and hepatitis B virus (HBV)-specific CD8⁺ T cells are centrally involved in the HBV immune response.**

See this image and copyright information in PMC

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References

1. Honer Zu Siederdissen C, Cornberg M. The role of HBsAg levels in the current management of chronic HBV infection. Ann Gastroenterol. 2014;27:105–112. - PMC - PubMed
1. Ott JJ, Stevens GA, Groeger J, Wiersma ST. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine. 2012;30:2212–2219. doi: 10.1016/j.vaccine.2011.12.116. - PubMed
1. Peppa D, Gill US, Reynolds G, Easom NJ, Pallett LJ, Schurich A, et al. Upregulation of a death receptor renders antiviral T cells susceptible to NK cellmediated deletion. J Exp Med. 2013;210:99–114. doi: 10.1084/jem.20121172. - PMC - PubMed
1. Boonstra A, Woltman AM, Janssen HL. Immunology of hepatitis B and hepatitis C virus infections. Best Pract Res Clin Gastroenterol. 2008;22:1049–1061. doi: 10.1016/j.bpg.2008.11.015. - PubMed
1. Ganem D, Prince AM. Hepatitis B virus infection-natural history and clinical consequences. N Engl J Med. 2004;350:1118–1129. doi: 10.1056/NEJMra031087. - PubMed

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[1] Honer Zu Siederdissen C, Cornberg M. The role of HBsAg levels in the current management of chronic HBV infection. Ann Gastroenterol. 2014;27:105–112. - PMC - PubMed

[2] Honer Zu Siederdissen C, Cornberg M. The role of HBsAg levels in the current management of chronic HBV infection. Ann Gastroenterol. 2014;27:105–112. - PMC - PubMed

[3] Ott JJ, Stevens GA, Groeger J, Wiersma ST. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine. 2012;30:2212–2219. doi: 10.1016/j.vaccine.2011.12.116. - PubMed

[4] Ott JJ, Stevens GA, Groeger J, Wiersma ST. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine. 2012;30:2212–2219. doi: 10.1016/j.vaccine.2011.12.116. - PubMed

[5] Peppa D, Gill US, Reynolds G, Easom NJ, Pallett LJ, Schurich A, et al. Upregulation of a death receptor renders antiviral T cells susceptible to NK cellmediated deletion. J Exp Med. 2013;210:99–114. doi: 10.1084/jem.20121172. - PMC - PubMed

[6] Peppa D, Gill US, Reynolds G, Easom NJ, Pallett LJ, Schurich A, et al. Upregulation of a death receptor renders antiviral T cells susceptible to NK cellmediated deletion. J Exp Med. 2013;210:99–114. doi: 10.1084/jem.20121172. - PMC - PubMed

[7] Boonstra A, Woltman AM, Janssen HL. Immunology of hepatitis B and hepatitis C virus infections. Best Pract Res Clin Gastroenterol. 2008;22:1049–1061. doi: 10.1016/j.bpg.2008.11.015. - PubMed

[8] Boonstra A, Woltman AM, Janssen HL. Immunology of hepatitis B and hepatitis C virus infections. Best Pract Res Clin Gastroenterol. 2008;22:1049–1061. doi: 10.1016/j.bpg.2008.11.015. - PubMed

[9] Ganem D, Prince AM. Hepatitis B virus infection-natural history and clinical consequences. N Engl J Med. 2004;350:1118–1129. doi: 10.1056/NEJMra031087. - PubMed

[10] Ganem D, Prince AM. Hepatitis B virus infection-natural history and clinical consequences. N Engl J Med. 2004;350:1118–1129. doi: 10.1056/NEJMra031087. - PubMed

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The Role of Immune Cells in Chronic HBV Infection

Affiliation

The Role of Immune Cells in Chronic HBV Infection

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Abstract

Conflict of interest statement

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