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Review
. 2016 Apr 2;12(4):907-15.
doi: 10.1080/21645515.2015.1119345. Epub 2016 Jan 25.

Impact of host genetic polymorphisms on vaccine induced antibody response

Janina E Linnik  1   2   3 , Adrian Egli  1   4
Affiliations
Review

Impact of host genetic polymorphisms on vaccine induced antibody response

Janina E Linnik et al. Hum Vaccin Immunother. .

Abstract

Many host- and vaccine-specific factors modulate an antibody response. Host genetic polymorphisms, in particular, modulate the immune response in multiple ways on different scales. This review article describes how information on host genetic polymorphisms and corresponding immune cascades may be used to generate personalized vaccine strategies to optimize the antibody response.

Keywords: GWAS; Influenza; Measles; SNP; antibodies; genetic polymorphism; immune response; individualized vaccination; systems biology; vaccine.

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Figures

Figure 1.
Figure 1.
Selected factors for a successful vaccination.
Figure 2.
Figure 2.
Multiscale impact of single nucleotide polymorphisms (SNPs).
Figure 3.
Figure 3.
Bibliometric map automatically created with Visualization of Similarity (VOS) viewer. Scientific terms are clustered with respect to their co-occurrence in title and abstract of PubMed references, which are published over the last 3 y (2013/01/01 - 2015/08/14) with ‘vaccination’, ‘vaccine’, ‘humoral immune response’, ‘single nucleotide polymorphism(s)’ or ‘SNP(s)' in title. Term proximity reflects co-occurrence and term size reflects occurrence frequency. Genetic terms (blue cluster) overlap with cancer terms (yellow cluster) and show close proximity to immunobiological terms (green cluster). In contrast, clinical and vaccination terms (red cluster) are almost separated from genetic terms. Bridging terms are for instance ‘liver transplantation’, ‘chronic hepatitis' and ‘ethnicity’. In total, 4,366 terms from 16,658 references are clustered.
See this image and copyright information in PMC

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