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. 1989 Sep;24(3):431-6.
doi: 10.1093/jac/24.3.431.

Penetration of ceftazidime into intracranial abscess

H T Green  1 , M A O'Donoghue, M D Shaw, C Dowling
Affiliations

Penetration of ceftazidime into intracranial abscess

H T Green et al. J Antimicrob Chemother. 1989 Sep.

Abstract

The penetration of ceftazidime into intracranial abscess was investigated in nine patients receiving intravenous ceftazidime. Concentrations of antibiotic in pus were measured by a microbiological agar diffusion assay (12 samples) and high performance liquid chromatography (8 samples) at varying times following ceftazidime administration. Concentrations of ceftazidime varying between 2.7 and 27.0 mg/l were detected. The role of ceftazidime in the therapy of intra-cranial abscess of otogenic origin is discussed.

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