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Comment
. 2016 Feb 2;113(5):E496-7.
doi: 10.1073/pnas.1519903113. Epub 2016 Jan 25.

MINCR is not a MYC-induced lncRNA

Jonathan R Hart  1 , Marc S Weinberg  2 , Kevin V Morris  3 , Thomas C Roberts  4 , Kim D Janda  5 , Amanda L Garner  6 , Peter K Vogt  7
Affiliations
Comment

MINCR is not a MYC-induced lncRNA

Jonathan R Hart et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Expression levels of MINCR plotted against levels of MYC taken from normal tissues and cell lines (Left, data from ref. 2) and Burkitt lymphoma cell lines (Right, data from ref. 3) show a lack of significant positive correlation between MYC and MINCR. FPKM, fragments per kilobase of transcript per million mapped reads.
See this image and copyright information in PMC

Comment in

Comment on

  • MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells.
    Doose G, Haake A, Bernhart SH, López C, Duggimpudi S, Wojciech F, Bergmann AK, Borkhardt A, Burkhardt B, Claviez A, Dimitrova L, Haas S, Hoell JI, Hummel M, Karsch D, Klapper W, Kleo K, Kretzmer H, Kreuz M, Küppers R, Lawerenz C, Lenze D, Loeffler M, Mantovani-Löffler L, Möller P, Ott G, Richter J, Rohde M, Rosenstiel P, Rosenwald A, Schilhabel M, Schneider M, Scholz I, Stilgenbauer S, Stunnenberg HG, Szczepanowski M, Trümper L, Weniger MA; ICGC MMML-Seq Consortium; Hoffmann S, Siebert R, Iaccarino I. Doose G, et al. Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5261-70. doi: 10.1073/pnas.1505753112. Epub 2015 Sep 8. Proc Natl Acad Sci U S A. 2015. PMID: 26351698 Free PMC article.

References

    1. Doose G, et al. MINCR is a MYC-induced lncRNA able to modulate MYC’s transcriptional network in Burkitt lymphoma cells. Proc Natl Acad Sci USA. 2015;112(38):E5261–E5270. - PMC - PubMed
    1. Cabili MN, et al. Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses. Genes Dev. 2011;25(18):1915–1927. - PMC - PubMed
    1. Barretina J, et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012;483(7391):603–607. - PMC - PubMed
    1. Zheng GX, Do BT, Webster DE, Khavari PA, Chang HY. Dicer-microRNA-Myc circuit promotes transcription of hundreds of long noncoding RNAs. Nat Struct Mol Biol. 2014;21(7):585–590. - PMC - PubMed
    1. Hart JR, et al. Inhibitor of MYC identified in a Kröhnke pyridine library. Proc Natl Acad Sci USA. 2014;111(34):12556–12561. - PMC - PubMed

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