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Review
. 2016 Jan 14;22(2):519-33.
doi: 10.3748/wjg.v22.i2.519.

Adjuvant chemotherapy for resected colorectal cancer metastases: Literature review and meta-analysis

Giovanni Brandi  1 , Stefania De Lorenzo  1 , Margherita Nannini  1 , Stefania Curti  1 , Marta Ottone  1 , Filippo Gustavo Dall'Olio  1 , Maria Aurelia Barbera  1 , Maria Abbondanza Pantaleo  1 , Guido Biasco  1
Affiliations
Review

Adjuvant chemotherapy for resected colorectal cancer metastases: Literature review and meta-analysis

Giovanni Brandi et al. World J Gastroenterol. .

Abstract

Surgical resection is the only option of cure for patients with metastatic colorectal cancer (CRC). However, the risk of recurrence within 18 mo after metastasectomy is around 75% and the liver is the most frequent site of relapse. The current international guidelines recommend an adjuvant therapy after surgical resection of CRC metastases despite the lower level of evidence (based on the quality of studies in this setting). However, there is still no standard treatment and the effective role of an adjuvant therapy remains controversial. The aim of this review is to report the state-of-art of systemic chemotherapy and regional chemotherapy with hepatic arterial infusion in the management of patients after resection of metastases from CRC, with a literature review and meta-analysis of the relevant randomized controlled trials.

Keywords: Adjuvant chemotherapy; Adjuvant hepatic artery infusion; Colorectal cancer; Liver metastases; Metastasectomy.

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Figures

Figure 1
Figure 1
Meta-analysis of the effects of systemic adjuvant chemotherapy studies after metastasectomy vs surgery alone (outcome, 5-year OS). The tegafur-uracil/leucovorin trial is not included in the meta-analysis because the follow-up period is not yet completed. Fixed effect model.
See this image and copyright information in PMC

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