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Review
. 2016 Jan 14;22(2):582-99.
doi: 10.3748/wjg.v22.i2.582.

Insight to drug delivery aspects for colorectal cancer

Arvind Gulbake  1 , Aviral Jain  1 , Ashish Jain  1 , Ankit Jain  1 , Sanjay K Jain  1
Affiliations
Review

Insight to drug delivery aspects for colorectal cancer

Arvind Gulbake et al. World J Gastroenterol. .

Abstract

Colorectal cancer (CRC) is the third most common cancer diagnosed worldwide in human beings. Surgery, chemotherapy, radiotherapy and targeted therapies are the conventional four approaches which are currently used for the treatment of CRC. The site specific delivery of chemotherapeutics to their site of action would increase effectiveness with reducing side effects. Targeted oral drug delivery systems based on polysaccharides are being investigated to target and deliver chemotherapeutic and chemopreventive agents directly to colon and rectum. Site-specific drug delivery to colon increases its concentration at the target site, and thus requires a lower dose and hence abridged side effects. Some novel therapies are also briefly discussed in article such as receptor (epidermal growth factor receptor, folate receptor, wheat germ agglutinin, VEGF receptor, hyaluronic acid receptor) based targeting therapy; colon targeted proapoptotic anticancer drug delivery system, gene therapy. Even though good treatment options are available for CRC, the ultimate therapeutic approach is to avert the incidence of CRC. It was also found that CRCs could be prevented by diet and nutrition such as calcium, vitamin D, curcumin, quercetin and fish oil supplements. Immunotherapy and vaccination are used nowadays which are showing better results against CRC.

Keywords: Colorectal cancer; Gene delivery; Receptor based targeted therapy.

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Figures

Figure 1
Figure 1
Basic causes of colorectal cancer.
Figure 2
Figure 2
Schematic representation of different targeting approaches for colorectal cancer.
See this image and copyright information in PMC

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