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. 1989 Nov;109(5):2547-54.
doi: 10.1083/jcb.109.5.2547.

Immunoelectron microscopic studies of type X collagen in endochondral ossification

A R Poole  1 , I Pidoux
Affiliations

Immunoelectron microscopic studies of type X collagen in endochondral ossification

A R Poole et al. J Cell Biol. 1989 Nov.

Abstract

Immunofluorescence and immunoelectron microscopy were used in conjunction with a monoclonal antibody to investigate the localization of type X collagen in the proximal tibial growth plate of 7-d-old chicks. This molecule was detected throughout the hypertrophic zone first appearing when chondrocytes exhibited hypertrophy: it was absent from the proliferative zone. Type X collagen was primarily associated with type II collagen fibrils as demonstrated by immunogold staining. Type X collagen was not concentrated in the focal calcification sites nor was it associated with matrix vesicles. These observations suggest that type X collagen may play a role other than that directly related to the nucleation of calcification.

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References

    1. J Orthop Res. 1987;5(2):157-63 - PubMed
    1. J Biol Chem. 1986 Mar 25;261(9):4184-9 - PubMed
    1. J Clin Invest. 1985 Aug;76(2):716-22 - PubMed
    1. J Biol Chem. 1985 Mar 25;260(6):3798-803 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 Mar;80(5):1322-6 - PubMed

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