Clinical Trial
Acceleration of growth in Turner syndrome patients treated with growth hormone: summary of three-year results
Affiliations
- PMID: 2681348
Item in Clipboard
Clinical Trial
Acceleration of growth in Turner syndrome patients treated with growth hormone: summary of three-year results
J Endocrinol Invest.
1989.
Abstract
In 1983, a multicenter, collaborative, prospective study was begun to investigate the efficacy of human growth hormone (hGH), alone and in combination with oxandrolone, in girls with Turner syndrome. While subjects in the control group grew 3.8 cm/yr (-0.1 SD for untreated Turner patients), subjects receiving hGH alone grew 6.6, 5.4 and 4.6 cm/yr in years 1-3, respectively (+3.1, +2.0, +1.4 SD). Subjects in the combination therapy group grew 9.8, 7.4 and 6.1 cm/yr (+6.6, +4.3, +3.0 SD). Turner subjects in both treatment groups showed increased in Bayley-Pinneau predicted adult heights and in Turner projected adult heights.
Similar articles
-
Growth hormone therapy in Turner's syndrome: an update on final height. Genentech National Cooperative Study Group.Acta Paediatr Suppl. 1992 Sep;383:3-6; discussion 7. Acta Paediatr Suppl. 1992. PMID: 1458013 Clinical Trial.
-
Methionyl human growth hormone and oxandrolone in Turner syndrome: preliminary results of a prospective randomized trial.J Pediatr. 1986 Dec;109(6):936-43. doi: 10.1016/s0022-3476(86)80272-4. J Pediatr. 1986. PMID: 3537249 Clinical Trial.
-
Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome.J Pediatr. 1992 Jul;121(1):49-55. doi: 10.1016/s0022-3476(05)82540-5. J Pediatr. 1992. PMID: 1625092 Clinical Trial.
-
[Possibilities to increase the efficacy of growth hormone therapy in Turner syndrome].Orv Hetil. 1997 Jun 8;138(23):1501-5. Orv Hetil. 1997. PMID: 9254366 Review. Hungarian.
-
[Turner syndrome: a virtually certain indication for growth hormone treatment].Tijdschr Kindergeneeskd. 1992 Oct;60(5):155-63. Tijdschr Kindergeneeskd. 1992. PMID: 1448805 Review. Dutch.
Cited by
-
Oxandrolone for growth hormone-treated girls aged up to 18 years with Turner syndrome.Cochrane Database Syst Rev. 2019 Oct 30;2019(10):CD010736. doi: 10.1002/14651858.CD010736.pub2. Cochrane Database Syst Rev. 2019. PMID: 31684688 Free PMC article.
-
Effect of oxandrolone therapy on adult height in Turner syndrome patients treated with growth hormone: a meta-analysis.Int J Pediatr Endocrinol. 2015;2015(1):18. doi: 10.1186/s13633-015-0013-3. Epub 2015 Aug 26. Int J Pediatr Endocrinol. 2015. PMID: 26322078 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical