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Review
. 2016 Jan 2;7(1):81-9.
doi: 10.14336/AD.2015.0803. eCollection 2016 Jan.

Chronic Inflammatory Diseases and Endothelial Dysfunction

Xavier Castellon  1 , Vera Bogdanova  1
Affiliations
Review

Chronic Inflammatory Diseases and Endothelial Dysfunction

Xavier Castellon et al. Aging Dis. .

Abstract

Chronic inflammatory diseases are associated with increases in cardiovascular diseases (CVD) and subclinical atherosclerosis as well as early-stage endothelial dysfunction screening using the FMD method (Flow Mediated Dilation). This phenomenon, referred to as accelerated pathological remodeling of arterial wall, could be attributed to traditional risk factors associated with atherosclerosis. Several new non-invasive techniques have been used to study arterial wall's structural and functional alterations. These techniques (based of Radio Frequency, RF) allow for an assessment of artery age through calculations of intima-media thickness (RF- QIMT), pulse wave rate (RF- QAS) and endothelial dysfunction degree (FMD). The inflammatory and autoimmune diseases should now be considered as new cardiovascular risk factors, result of the major consequences of oxidative stress and RAS (Renin Angiotensin System) imbalance associated with the deleterious effect of known risk factors that lead to the alteration of the arterial wall. Inflammation plays a key role in all stages of the formation of vascular lesions maintained and exacerbated by the risk factors. The consequence of chronic inflammation is endothelial dysfunction that sets in and we can define it as an integrated marker of the damage to arterial walls by classic risk factors. The atherosclerosis, which develops among these patients, is the main cause for cardiovascular morbi-mortality and uncontrolled chronic biological inflammation, which quickly favors endothelial dysfunction. These inflammatory and autoimmune diseases should now be considered as new cardiovascular risk factors.

Keywords: FMD; atherosclerosis; endothelial dysfunction; inflammatory diseases; non-invasive artery age testing methods.

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Figures

Figure 1.
Figure 1.
The genesis of the inflammatory plaque and endothelial dysfunction. Penetration and accumulation of lipoproteins in the intima LDL = by passive phenomenon Modification of LDL oxidized LDL.
Figure 2.
Figure 2.
Chronic inflammatory diseases and endothelial dysfunction
See this image and copyright information in PMC

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