Vascular restoration therapy and bioresorbable vascular scaffold

Abstract

This article describes the evolution of minimally invasive intervention technologies for vascular restoration therapy from early-stage balloon angioplasty in 1970s, metallic bare metal stent and metallic drug-eluting stent technologies in 1990s and 2000s, to bioresorbable vascular scaffold (BVS) technology in large-scale development in recent years. The history, the current stage, the challenges and the future of BVS development are discussed in detail as the best available approach for vascular restoration therapy. The criteria of materials selection, design and processing principles of BVS, and the corresponding clinical trial results are also summarized in this article.

Keywords: bioresorbable vascular scaffold; bioresorbable/biodegradable material; drug-eluting biodegradable stent; drug-eluting bioresorbable scaffold; drug-eluting stent; vascular disease; vascular reparative therapy; vascular restoration therapy.