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Review
. 2013 Dec;2(4):301-11.
doi: 10.3978/j.issn.2223-4683.2013.12.01.

Dapoxetine and the treatment of premature ejaculation

Premsant Sangkum  1 , Rhamee Badr  1 , Ege Can Serefoglu  2 , Wayne J G Hellstrom  1
Affiliations
Review

Dapoxetine and the treatment of premature ejaculation

Premsant Sangkum et al. Transl Androl Urol. 2013 Dec.

Abstract

Background: Premature ejaculation (PE) is the most common male sexual complaint. Off-label oral selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for the treatment of PE. Dapoxetine is a short-acting SSRI specifically designed for on-demand use. The objective of this communication is to summarize the clinical and physiological evidence regarding the role of the serotonergic pathway and specifically dapoxetine in the treatment of PE.

Methods: A PubMed search was conducted on articles reporting data on dapoxetine for the treatment of PE. Articles describing the pathophysiology and treatment options for PE were additionally included for review.

Results: The etiology of PE is multi-factorial in nature. There are many treatment options for PE such as psychological/behavioral therapy, topical anesthetic agents, phosphodiesterase type 5 (PDE-5) inhibitors, and tramadol hydrochloride. SSRIs play a major role in PE treatment. Animal and clinical studies in addition to its pharmacokinetic document dapoxetine's clinical efficacy and safety for on-demand treatment of PE.

Conclusions: Dapoxetine demonstrates clinical efficacy and a favorable side effect profile. Dapoxetine is currently the oral drug of choice for on-demand treatment of PE.

Keywords: Dapoxetine; premature ejaculation (PE); selective serotonin reuptake inhibitor (SSRI).

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Conflict of interest statement

Conflicts of Interest: Ege Can Serefoglu is consultant for Allergan Inc. Irvwine, CA, USA. Wayne J.G. Hellstrom: American Medical Systems—Consultant or Advisor; Andromedical—Consultant or Advisor; Auxilium—Meeting Participant or Lecturer, Consultant or Advisor, Investigator; Allergan—Consultant or Advisor, Scientific Study or Trial; Coloplast—Consultant or Advisor, Investigator; Cook—Consultant or Advisor, Lecturer; Endo—Consultant or Advisor, Investigator, Lecturer; Johnson & Johnson—Consultant or Advisor, Meeting Participant or Lecturer, Investigator; Lilly, USA—Consultant or Advisor, Lecturer; NIH—Board Member, Officer, Trustee; Slate Pharmaceutical—Lecturer, Advisor, and Investigator; Theralogix—Board Member, Officer, Trustee; VIVUS—Advisor/Consultant, Investigator, Lecturer. And Premsant Sangkum and Rhamee Badr have no conflicts of interest to declare.

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References

    1. Waldinger MD. The neurobiological approach to premature ejaculation. J Urol 2002;168:2359-67. - PubMed
    1. Jannini EA, Lenzi A. Epidemiology of premature ejaculation. Curr Opin Urol 2005;15:399-403. - PubMed
    1. International Classification of Diseases and Related Health Problems. 10 ed. Geniva: World Health Organization, 1994.
    1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders 4th Ed. Text Revision. Washington, D.C.: American Psychiatric Publishing Inc, 2000.
    1. Rowland D, Mcmahon CG, Abdo C, et al. Disorders of orgasm and ejaculation in men. J Sex Med 2010;7:1668-86. - PubMed