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. 2015 Dec;9(12):ZC10-2.
doi: 10.7860/JCDR/2015/14729.6922. Epub 2015 Dec 1.

Fibrinogen Degradation Products and Periodontitis: Deciphering the Connection

Shweta Dikshit  1
Affiliations

Fibrinogen Degradation Products and Periodontitis: Deciphering the Connection

Shweta Dikshit. J Clin Diagn Res. 2015 Dec.

Abstract

Introduction: Fibrinogen degradation products (e.g. D-dimer) arise from digested fibrin clots and fibrinogen. Elevated concentrations accompany activation of coagulation and fibrinolysis and indicate chronic inflammatory diseases. D-Dimer tests are a quick, noninvasive method to rule out abnormal clotting. Periodontitis strongly affects the haemostatic system and evokes a procoagulant state. Correlation of chronic periodontitis with early indicators of disease (biomarkers) might be useful.

Aim: The aim of the study was to examine whether the plasma D-dimer concentration reflects the progression of chronic periodontitis and the beneficial effect of periodontal therapy.

Materials and methods: Forty randomly selected subjects were divided into four groups, Group I: 10 healthy subjects, Group II: 10 with mild periodontitis, Group III: 10 with moderate periodontitis, Group IV: 10 with severe periodontitis. After thorough dental and periodontal examination, 3 mL of venous blood was collected for measurement of fibrinogen degradation products.

Results: The patients with moderate and chronic periodontitis exhibited high concentrations of D-dimer (mean value 434.98-535.52 mcg/mL), whereas subjects with mild or no periodontitis exhibited values of 329.78-211.29 mcg/mL. Concentrations of D-dimer were significantly reduced after therapy of all classes of periodontitis.

Conclusion: Periodontal treatment can reduce amount of D-dimer in the plasma. A higher than normal concentration is observed in chronic periodontitis.

Keywords: Biomarker; D-dimer; Fibronolysis; Periodontal disease.

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Figures

[Table/Fig-2]:
[Table/Fig-2]:
Plaque index depicting high scores with increasing severity of periodontitis
[Table/Fig-4]:
[Table/Fig-4]:
There was a significant improvement in the serum FDP concentration in all groups
See this image and copyright information in PMC

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