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Case Reports
. 2016 Jan 27:10:24.
doi: 10.1186/s13256-016-0810-1.

Concurrent colonic mucosa-associated lymphoid tissue lymphoma and adenoma diagnosed after a positive fecal occult blood test: a case report

Pei-Chiang Lin  1 , Jinn-Shiun Chen  2 , Po Deng  3 , Chih-Wei Wang  4 , Chiung-Huei Huang  5 , Reiping Tang  2   6 , Jy-Ming Chiang  2 , Chien-Yuh Yeh  2 , Pao-Shiu Hsieh  2 , Wen-Sy Tsai  2 , Sum-Fu Chiang  7
Affiliations
Case Reports

Concurrent colonic mucosa-associated lymphoid tissue lymphoma and adenoma diagnosed after a positive fecal occult blood test: a case report

Pei-Chiang Lin et al. J Med Case Rep. .

Abstract

Background: Colonic lymphoma is an uncommon presentation of extranodal lymphoma. Colonic mucosa-associated lymphoid tissue lymphoma is a different entity from gastric mucosa-associated lymphoid tissue lymphoma, and very rare. The presentation and management of colonic mucosa-associated lymphoid tissue are highly variable in the literature.

Case presentation: We report the case of a 59-year-old Taiwanese man who underwent a colonoscopy after a positive test for fecal occult blood. His past history included hypertension and hyperthyroidism. The colonoscopy revealed an adenomatous polyp and mucosa-associated lymphoid tissue lymphoma. We successfully performed a polypectomy and endoscopic mucosal resection. The lymphoma was staged according to the Ann Arbor system modified by Musshoff as E-I. Our patient showed no lymphoma recurrence over a 3-year follow-up.

Conclusions: Endoscopic mucosal resection for colonic mucosa-associated lymphoid tissue lymphoma without disseminated disease may be feasible. We successfully used colonoscopic treatment without adjuvant therapy to treat early-stage pathogen-free colonic mucosa-associated lymphoid tissue lymphoma.

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Figures

Fig. 1
Fig. 1
Complete colonoscopy revealed a flat polyp located 35 cm from the anal verge (a). Pathology identified it as an adenomatous polyp. Another 2.0 cm polypoid polyp was found 25 cm from the anal verge (b). It was polypoid with a wide base, slightly irregular border, and an irregular vascular pattern with mild inflammatory changes. We removed the second lesion (shown in b) by endoscopic mucosal resection (c), followed by the application of one hemoclip for wound closure (d)
Fig. 2
Fig. 2
Pathology of the larger polypoid polyp revealed polypoid colonic mucosa with atypical lymphoid cells infiltrating the lamina propria (a). An immunohistochemical study found that the specimen was positive for CD20, CD5, and Bcl-2, and negative for CD10 and cyclin D1, which supported the diagnosis of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue lymphoma type (b). The resected specimen is positive for lymphoma cells, which are present at the cauterized margin (left side of the figure; hematoxylin and eosin stain, 100×) (c)
See this image and copyright information in PMC

References

    1. Koch P, del Valle F, Berdel WE, Willich NA, Reers B, Hiddemann W, et al. Primary gastrointestinal non-Hodgkin’s lymphoma: I. Anatomic and histologic distribution, clinical features, and survival data of 371 patients registered in the German Multicenter Study GIT NHL 01/92. J Clin Oncol. 2001;19(18):3861–73. - PubMed
    1. Psyrri A, Papageorgiou S, Economopoulos T. Primary extranodal lymphomas of stomach: clinical presentation, diagnostic pitfalls and management. Ann Oncol. 2008;19(12):1992–9. doi: 10.1093/annonc/mdn525. - DOI - PMC - PubMed
    1. Doolabh N, Anthony T, Simmang C, Bieligk S, Lee E, Huber P, et al. Primary colonic lymphoma. J Surg Oncol. 2000;74(4):257–62. doi: 10.1002/1096-9098(200008)74:4<257::AID-JSO3>3.0.CO;2-U. - DOI - PubMed
    1. Fan CW, Changchien CR, Wang JY, Chen JS, Hsu KC, Tang R, et al. Primary colorectal lymphoma. Dis Colon Rectum. 2000;43(9):1277–82. doi: 10.1007/BF02237436. - DOI - PubMed
    1. Pileri SA, Milani M, Fraternali-Orcioni G, Sabattini E. From the REAL-classification to the upcoming WHO-scheme: a step towards universal categorization of lymphoma’s entities? Ann Oncol. 1998;9(6):607–12. doi: 10.1023/A:1008278706002. - DOI - PubMed

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