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Review
. 2016 Mar;17(3):170-82.
doi: 10.1038/nrm.2015.27. Epub 2016 Jan 28.

Pluripotent stem cells in disease modelling and drug discovery

Yishai Avior  1 , Ido Sagi  1 , Nissim Benvenisty  1
Affiliations
Review

Pluripotent stem cells in disease modelling and drug discovery

Yishai Avior et al. Nat Rev Mol Cell Biol. 2016 Mar.

Abstract

Experimental modelling of human disorders enables the definition of the cellular and molecular mechanisms underlying diseases and the development of therapies for treating them. The availability of human pluripotent stem cells (PSCs), which are capable of self-renewal and have the potential to differentiate into virtually any cell type, can now help to overcome the limitations of animal models for certain disorders. The ability to model human diseases using cultured PSCs has revolutionized the ways in which we study monogenic, complex and epigenetic disorders, as well as early- and late-onset diseases. Several strategies are used to generate such disease models using either embryonic stem cells (ES cells) or patient-specific induced PSCs (iPSCs), creating new possibilities for the establishment of models and their use in drug screening.

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References

    1. Nat Rev Genet. 2014 Aug;15(8):517-30 - PubMed
    1. Hum Mol Genet. 2011 Dec 1;20(23):4530-9 - PubMed
    1. Nature. 2009 Sep 17;461(7262):402-6 - PubMed
    1. Prenat Diagn. 1999 Feb;19(2):142-5 - PubMed
    1. Cell Stem Cell. 2014 Nov 6;15(5):634-42 - PubMed

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